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Emphysema's Holy Grail, The Quest for Endobronchial Lung Volume Reduction

James D Maloney* and Ryan A Macke

Department of Surgery, Cardiothoracic Surgery, University of Wisconsin, USA

*Corresponding Author:
Maloney JD
Associate Professor of Surgery, Section Chief-Thoracic Surgery
University of Wisconsin, Department of Surgery
Cardiothoracic Surgery, 600 Highland Ave, H4/318, Madison
WI 53792-3236, USA
Tel: +27219593229/2190
Fax: +278615107002
E-mail: [email protected]

Received Date: July 27, 2016; Accepted Date: July 30, 2016; Published Date: August 04, 2016

Citation: Maloney JD, Macke RA (2016) Emphysema's Holy Grail, The Quest for Endobronchial Lung Volume Reduction. Chron Obstruct Pulmon Dis 1:13. doi: 10.21767/2572-5548.100013

Copyright: © 2016 Maloney JD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Chronic Obstructive Pulmonary Disease: Open Access

Letter to Editor,

Bronchoscopic lung volume reduction has become the Holy Grail of pulmonologists who treat COPD in both the United States and abroad. In some ways this if fitting as “chronic lower respiratory disease” is now the fourth leading cause of death in the US [1]. In addition, COPD severely impacts quality of life and is a significant cost burden [2]. Now more than five years ago Drs Ernst and Anantham published their review of Bronchoscopic lung volume reduction in Clinical Chest Medicine [3]. At that time endobronchial valve, airway bypass stent and biologic LVR trials had occurred though none proved to be of significant clinical value to warrant inclusion in standard COPD treatment algorithms. The most recent iteration of this quest is documented in JAMA regarding the RENEW endobronchial coil study. This technology was exciting as traction providing coils would not be subject to the crossventilation which has been implicated in the limited effect of endobronchial valves [4]. Unfortunately, Dr. Sciurba and colleagues found that the study patients benefit from the treatment was of “uncertain clinical importance, with a higher likelihood of major complications” [5]. As thoracic surgeons who also treat COPD, we sympathize with the authors as major complications are something with which we are all too familiar. My colleagues and I have reported the short term outcomes of Lung Volume Reduction Surgery (LVRS) from Society of Thoracic Surgery database review from 2003-2011, confirming that surgical intervention has risk of morbidity and mortality [6]. However, along with the risk of the procedure comes a documented significant benefit, demonstrated in both exercise capacity, subjective dyspnea and FEV1 [7,8]. Most importantly, Dr. Naunheim and colleagues found that in the upper lobe predominant, low exercise capacity sub group 5- year survival was improved over best medical management [8]. Though this data is readily available and relevant with the increasing numbers of severe emphysema patients, overall limited organ availability, and shift in lung allocation toward the fibrotic lung population, LVRS is still met with skepticism in the pulmonology community. As a group we must decide if we believe that reducing the volume of hyper-expanded COPD patients is effective in treating their symptoms and improving their quality, and perhaps quantity of life. The data certainly suggests this is the case. Despite this the volume of LVRS in the United States is surprisingly low relative to the prevalence of COPD. Education and discussion is needed between the thoracic surgical and medical community so that patients are given the opportunity to investigate their treatment options. While continuing the quest in a systematic and responsible way for the grail of an endoscopic approach, surgical LVRS remains an option in appropriately chosen patients at high volume centers with multidisciplinary programs.


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